Millennium & Copthorne Hotels has announced that Jennifer Fox will step down from her role as chief executive of the company with immediate effect.
Fox has only been in the role three months.
She will be replaced on an interim basis by Tan Kian Seng, the current group chief of staff.
Fox is a former president of Fairmont Hotels & Resorts, and previously spent ten years with InterContinental Hotels Group.
An industry veteran, with more than 30 years experience in the hospitality sector, she replaced Aloysius Lee, who had resigned in January.
No reasons for the departure were given.
The hotel group reported first half revenue fell to £477 million last month, compared to £485 million the previous year.