bmi regional has confirmed it will scrap five routes after a review of its operations.
The decision means the carrier will pull out of bases at Edinburgh, Birmingham and Manchester airports.
The airline became independent in 2012 after parent BMI was purchased by International Airlines Group, parent of British Airways.
The airline will keep Aberdeen and Bristol as its main hubs.
The routes being scrapped are Manchester to Edinburgh and Antwerp; Birmingham to Billund; and Edinburgh to Copenhagen and Brussels.
bmi regional said it did not expect any job losses as a result of the changes.
Last week bmi regional announced a new route from Newcastle to Brussels and launched services between Aberdeen and Oslo on Monday.