Brittany Ferries has announced the end of industrial action at the line, with staff having agreed to a new pay deal.
Services are now set to resume on Tuesday afternoon.
Staff began a series of wildcat strikes are the ferry operator late last month, with Brittany responding by cancelling all sailings from September 21st.
The service offers sailings from Portsmouth, Poole and Plymouth to France and Spain.
A spokesman told the BBC a “majority” of crew members voted on Sunday to accept a deal which included “a number of concessions” by the firm which has been making losses for the last three years.
The first sailing on Tuesday is the 15:30 service from Poole to Cherbourg.