The World Economic Forum on Latin America brings together leaders from all sectors, as well as academic thought leaders and millennials, to explore how a new prosperity agenda can be actively shaped. Returning to Colombia and hosted in the city of Medellín, the meeting gathers at a remarkable place and time: Medellín’s transformation over the past two decades is a stark example of successful 21st-century urban innovation. At the same time, Colombia is close to a historic accord that promises opportunities for sustained peace, economic progress and social inclusion. These inspiring achievements teach valuable lessons and are a reminder that socio-economic advances require constant attention as well as concerted and strategic action.