Opodo has confirmed chief executive Ignacio Martos will leave the company after five years.
He will be replaced by eDreams chief executive Javier Perez-Tenessa following the merger of Opodo, eDreams and Go Voyages.
The move comes after Amadeus announced it would be selling Opodo to AXA Private Equity and Permira Funds for €450 million.
Amadeus has been seeking a buyer for Opodo since October 2010 after it announced the company was no longer a strategic asset.
Internet travel agency Opodo was founded by a consortium of European airlines, including British Airways, Air France, Alitalia, Iberia, KLM, Lufthansa, Aer
Lingus, Austrian Airlines and Finnair.
Amadeus presently owns 99.4 per cent of the organisation.